BULLETINS

Hijacking of host metabolic machinery by viral proteins and host genomic reprogramming by viral RNA, is critical for viral biogenesis and propagation. During the pathogenesis, SARS-CoV-2 reprograms and dysregulates several host cellular pathways that involve metabolism, bioenergetics, iron-redox signaling, and immunity – collectively termed as viral-induced HMR/D. Pathophysiological manifestations of HMR/D in acute onset of COVID-19 and during chronic persistence of PASC is a cumulative outcome of metabolic remodeling culminating