RESET

LIFE is a genetic-programmed, highly organized, chemical processing thermo-dynamic system, that self-sustains by breaking chemical bonds (catabolism) to release and capture free energy to form complex macro-molecules (anabolism) for specific structure-function (metabolism) in a lipid-based envelope, known as the ‘CELL’. Viruses infect almost every species and are probably the most abundant biological entities on the planet. Recently emerged coronavirus, the SARS-CoV-2, is a 29.9-kb RNA virus that harbors a unique genomic ability to reprogram a mega-sized 3.1-Mb human DNA and its cellular metabolic machinery to prime, alter, and redirect host macro-molecules for its infection, progeny, and propagation. The 14 viral open reading frames (ORFs) interact with few thousands of human metabolites in a specific manner to facilitate intra-cellular invasion, replication, and transmission, which results in HMR/D in favor of the viral pathogen. Genomic and meta-genomic data have revealed that co-evolution between viral and cellular genomes involves frequent horizontal gene transfer and the occasional co-option of novel functions over evolutionary time – the viral-induced HMR/D in PASC is one such prime example. Therefore, the nutraceutical and food technology professionals should take a serious note that designing a RESET composition is not a simple blend of food compounds or nutritional ingredients into a dosage form. A deeper meta-genomic insight to assure 3-D structure/function of nutrient molecules, priming/activation of nutrients with co-factors, compositional stoichiometry, optimal milieu (pH, redox, and ionic strength), molecular interplay between bio-active compounds (synergism/ antagonism), target delivery, ADME (absorption-distribution-metabolism-excretion)/Safety/Toxicity profiles, and most importantly the bio-functional activity, are vital prerequisites in the development of nutrient-based remedials to RESET the viral-induced HMR/D in PASC, the ‘new onset’ global metabolic syndrome. This precision nutrition-based dietary rehabilitation in combination with healthcare treatment of PASC patients should be developed as an affordable, interventional regimen for divergent socio-economic populations worldwide for effective public health management of any future emergence of viral-induced ‘new onset’ metabolic syndromes.